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An evaluation of the leishmanicidal activityin vitro andin vivo of hypericin, an expanded-spectrum photosensitizer found inHypericum perforatum , is presented. Hypericin was evaluated against intracellular amastigotesin vitro ofLeishmania (Viannia )panamensis . A topical formulation containing 0.5% hypericin was developed and assayedin vivo in a hamster model of cutaneous leishmaniasis. Results demonstrate that hypericin induces a significant antiamastigote effectin vitro againstL. panamensis by decreasing the number of parasites inside infected cells. The topical formulation of 0.5% hypericin allows healing ofL. panamensis -induced lesions upon a topical application of 40 mg/day plus visible-light irradiation (5 J/cm2 , 15 min), twice a week for 3 weeks.

antimicrobial agents and chemotherapy

Development of a Novel Formulation with Hypericin To Treat Cutaneous Leishmaniasis Based on Photodynamic Therapy in<i>In Vitro</i>and<i>In Vivo</i>Studies

Development of a Novel Formulation with Hypericin To Treat Cutaneous Leishmaniasis Based on Photodynamic Therapy inIn VitroandIn VivoStudies