Colistin Resistance in a Clinical Acinetobacter baumannii Strain Appearing after Colistin Treatment: Effect on Virulence and Bacterial Fitness | Zendy

Rafael López-Rojas | Zendy; Michael J. McConnell | Zendy; Jiménez-Mejías Me | Zendy; Juan Domínguez-Herrera | Zendy; Felipe Fernández-Cuenca | Zendy; Jerónimo Pachón | Zendy

Open Access

Colistin Resistance in a Clinical Acinetobacter baumannii Strain Appearing after Colistin Treatment: Effect on Virulence and Bacterial Fitness

Author(s) -

Rafael López-Rojas,

Michael J. McConnell,

Jiménez-Mejías Me,

Juan Domínguez-Herrera,

Felipe Fernández-Cuenca,

Jerónimo Pachón

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00543-13

Subject(s) - acinetobacter baumannii , colistin , microbiology and biotechnology , virulence , acinetobacter , strain (injury) , biology , drug resistance , medicine , bacteria , antibiotics , pseudomonas aeruginosa , gene , genetics , anatomy

The fitness and virulence costs associated with the clinical acquisition of colistin resistance by Acinetobacter baumannii were evaluated. The growth of strain CR17 (colistin resistant) was less than that of strain CS01 (colistin susceptible) when the strains were grown in competition (72-h competition index, 0.008). In a murine sepsis model, CS01 and CR17 reached spleen concentrations when coinfecting of 9.31 and 6.97 log10 CFU/g, respectively, with an in vivo competition index of 0.016. Moreover, CS01 was more virulent than CR17 with respect to mortality and time to death.

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