Trends in Susceptibility of Vancomycin-Resistant Enterococcus faecium to Tigecycline, Daptomycin, and Linezolid and Molecular Epidemiology of the Isolates: Results from the Tigecycline In Vitro Surveillance in Taiwan (TIST) Study, 2006 to 2010 | Zendy

Hsih-Yeh Tsai | Zendy; ChunHsing Liao | Zendy; YenHsu Chen | Zendy; PoLiang Lu | Zendy; Cheng-Hua Huang | Zendy; Chin-Te Lu | Zendy; Yin-Ching Chuang | Zendy; Shih-Ming Tsao | Zendy; Yao-Shen Chen | Zendy; Yung-Ching Liu | Zendy; WeiYu Chen | Zendy; Tsrang-Neng Jang | Zendy; HsiuChen Lin | Zendy; ChihMing Chen | Zendy; Zhi-Yuan Shi | Zendy; SungChing Pan | Zendy; Jia-Ling Yang | Zendy; HsiangChi Kung | Zendy; Chun-Eng Liu | Zendy; Yu-Jen Cheng | Zendy; Jien-Wei Liu | Zendy; Wu Sun | Zendy; Lih-Shinn Wang | Zendy; WenChien Ko | Zendy; Kwok-Woon Yu | Zendy; Ping-Cherng Chiang | Zendy; Ming-Hsun Lee | Zendy; Chun-Ming Lee | Zendy; GwoJong Hsu | Zendy; PoRen Hsueh | Zendy

Open Access

Trends in Susceptibility of Vancomycin-Resistant Enterococcus faecium to Tigecycline, Daptomycin, and Linezolid and Molecular Epidemiology of the Isolates: Results from the Tigecycline In Vitro Surveillance in Taiwan (TIST) Study, 2006 to 2010

Author(s) -

Hsih-Yeh Tsai,

ChunHsing Liao,

YenHsu Chen,

PoLiang Lu,

Cheng-Hua Huang,

Chin-Te Lu,

Yin-Ching Chuang,

Shih-Ming Tsao,

Yao-Shen Chen,

Yung-Ching Liu,

WeiYu Chen,

Tsrang-Neng Jang,

HsiuChen Lin,

ChihMing Chen,

Zhi-Yuan Shi,

SungChing Pan,

Jia-Ling Yang,

HsiangChi Kung,

Chun-Eng Liu,

Yu-Jen Cheng,

Jien-Wei Liu,

Wu Sun,

Lih-Shinn Wang,

WenChien Ko,

Kwok-Woon Yu,

Ping-Cherng Chiang,

Ming-Hsun Lee,

Chun-Ming Lee,

GwoJong Hsu,

PoRen Hsueh

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00533-12

Subject(s) - tigecycline , daptomycin , linezolid , enterococcus faecium , vancomycin , microbiology and biotechnology , medicine , vancomycin resistant enterococcus , antibiotics , biology , staphylococcus aureus , bacteria , genetics

Among the 219 vancomycin-resistant Enterococcus faecium isolates collected in 20 Taiwanese hospitals from 2006 to 2010, all were susceptible to linezolid and daptomycin, and 98.6% were susceptible to tigecycline. There was a shift toward higher tigecycline MIC values (MIC(90)s) from 2006-2007 (0.06 μg/ml) to 2008-2010 (0.12 μg/ml). The MIC(90)s of daptomycin and linezolid remained stationary. Although pulsotypes among the isolates from the 20 hospitals varied, intrahospital spreading of several clones was identified in 13 hospitals.

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