Open AccessPharmacodynamics of Doxycycline in a Murine Malaria Model
Author(s) -
Kevin T. Batty,
Angela S. F. Law,
Verity Stirling,
Brioni R. Moore
Publication year - 2007
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00529-07
Subject(s) - doxycycline , dihydroartemisinin , schizogony , malaria , pharmacology , pharmacodynamics , plasmodium berghei , medicine , plasmodium falciparum , biology , immunology , pharmacokinetics , antibiotics , microbiology and biotechnology , artemisinin
Doxycycline is reported to impair second-generation parasite schizogony. The effects of doxycycline alone and combined with dihydroartemisinin were investigated in a murine malaria model. Doxycycline lowered the rate of parasite growth within 2 days, with maximum effect in 6 days. Addition of dihydroartemisinin led to an additive antimalarial effect.