Increasing Chloramphenicol Resistance in Streptococcus pneumoniae Isolates from Papua New Guinean Children with Acute Bacterial Meningitis | Zendy

Laurens Manning | Zendy; Moses Laman | Zendy; Andrew R. Greenhill | Zendy; Audrey Michael | Zendy; Peter Siba | Zendy; Ivo Mueller | Zendy; Timothy M. E. Davis | Zendy

Open Access

Increasing Chloramphenicol Resistance in Streptococcus pneumoniae Isolates from Papua New Guinean Children with Acute Bacterial Meningitis

Author(s) -

Laurens Manning,

Moses Laman,

Andrew R. Greenhill,

Audrey Michael,

Peter Siba,

Ivo Mueller,

Timothy M. E. Davis

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00526-11

Subject(s) - chloramphenicol , streptococcus pneumoniae , microbiology and biotechnology , haemophilus influenzae , ceftriaxone , meningitis , biology , streptococcaceae , klebsiella pneumoniae , antibiotics , medicine , pediatrics , escherichia coli , biochemistry , gene

In Papua New Guinean (PNG) children with acute bacterial meningitis (ABM), all Haemophilus influenzae isolates were resistant to chloramphenicol. Although Streptococcus pneumoniae isolates had a median chloramphenicol MIC of 3 μg/ml, it was ≥4 μg/ml in 42.8%, and the likelihood of an area under the 24-hour concentration-time curve/MIC ratio of >100 h at a MIC of ≥4 μg/ml was approximately 50%. All isolates were ceftriaxone sensitive. These data support ceftriaxone rather than conventional chloramphenicol for all PNG children with suspected ABM.

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