Open AccessIn Vitro Activity of Daptomycin against Methicillin-Resistant Staphylococcus aureus , Including Heterogeneously Glycopeptide-Resistant Strains
Author(s) -
Bram M. W. Diederen,
Inge van Duijn,
Piet Willemse,
Jan Kluytmans
Publication year - 2006
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00526-06
Subject(s) - daptomycin , glycopeptide , etest , microbiology and biotechnology , staphylococcus aureus , methicillin resistant staphylococcus aureus , vancomycin , micrococcaceae , in vitro , biology , antibacterial agent , medicine , antibiotics , bacteria , biochemistry , genetics
The purpose of the present study was to assess the in vitro activity of daptomycin against a well-defined collection of methicillin-resistantStaphylococcus aureus (MRSA) isolates (n = 98), including heterogeneously glycopeptide-resistant MRSA (hGISA) strains. Susceptibility testing was performed by using the Etest system. Daptomycin was potent against both glycopeptide-susceptible and hGISA strains.