Oral Therapy with Amlodipine and Lacidipine, 1,4-Dihydropyridine Derivatives Showing Activity against Experimental Visceral Leishmaniasis | Zendy

Partha Palit | Zendy; Nahid Ali | Zendy

Open Access

Oral Therapy with Amlodipine and Lacidipine, 1,4-Dihydropyridine Derivatives Showing Activity against Experimental Visceral Leishmaniasis

Author(s) -

Partha Palit,

Nahid Ali

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00522-07

Subject(s) - lacidipine , amlodipine , pharmacology , dihydropyridine , leishmania donovani , chemistry , visceral leishmaniasis , medicine , leishmaniasis , calcium , biochemistry , antagonist , immunology , receptor , blood pressure

Amlodipine and lacidipine, conventional antihypertensive drugs, inhibited Leishmania donovani infection in vitro and in BALB/c mice when administered orally. These 1,4-dihydropyridine derivatives functioned through dose-dependent inhibition of oxygen consumption, triggering caspase 3-like activation-mediated programmed cell death of the parasites.

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