Candida albicans Infections in Renal Transplant Recipients: Effect of Caspofungin on Polymorphonuclear Cells | Zendy

Valeria Allizond | Zendy; Giuliana Banche | Zendy; F Giacchino | Zendy; Chiara Merlino | Zendy; Daniela Scalas | Zendy; Viviana Cristina Tullio | Zendy; G Garneri | Zendy; Narcisa Mandras | Zendy; Janira Roana | Zendy; Annamaria Cuffini | Zendy

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Candida albicans Infections in Renal Transplant Recipients: Effect of Caspofungin on Polymorphonuclear Cells

Author(s) -

Valeria Allizond,

Giuliana Banche,

F Giacchino,

Chiara Merlino,

Daniela Scalas,

Viviana Cristina Tullio,

G Garneri,

Narcisa Mandras,

Janira Roana,

Annamaria Cuffini

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00521-11

Subject(s) - caspofungin , candida albicans , granulocyte , microbiology and biotechnology , corpus albicans , immunosuppression , immunology , renal transplant , medicine , biology , antifungal , amphotericin b , transplantation

This study aimed to compare the caspofungin immunomodulating activities against Candida albicans on polymorphonuclear cells (PMNs) from renal transplant recipients (RTRs) and healthy subjects (HSs). RTR PMNs showed a significantly reduced fungicidal activity compared with that of HS PMNs. Addition of caspofungin to RTR PMNs significantly potentiated the yeast intracellular killing rate, achieving values similar to those observed for HS PMNs. These data show that caspofungin is suitable for invasive candidiasis treatment in patients with immune system-impaired components.

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