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Ceftobiprole is a fifth-generation cephalosporin approved for the treatment of pneumonia, with a broad antibacterial spectrum, including potent activity against methicillin-resistantStaphylococcus aureus . As for the other cephalosporins, high pharmacokinetic variability and concentration-dependent neurotoxicity are expected.

Validation and Application of an HPLC-DAD Method for Routine Therapeutic Drug Monitoring of Ceftobiprole