Slow Release of Nitric Oxide from Charged Catheters and Its Effect on Biofilm Formation by Escherichia coli | Zendy

G. Regev-Shoshani | Zendy; Mary Ko | Zendy; Christopher C.J. Miller | Zendy; Yossef AvGay | Zendy

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Slow Release of Nitric Oxide from Charged Catheters and Its Effect on Biofilm Formation by Escherichia coli

Author(s) -

G. Regev-Shoshani,

Mary Ko,

Christopher C.J. Miller,

Yossef AvGay

Publication year - 2009

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00511-09

Subject(s) - antiseptic , nitric oxide , biofilm , escherichia coli , microbiology and biotechnology , bacteria , catheter , urinary system , chemistry , bacterial growth , urinary catheterization , foley catheter , medicine , biology , surgery , biochemistry , genetics , organic chemistry , gene

Catheter-associated urinary tract infection is the most prevalent cause of nosocomial infections. Bacteria associated with biofilm formation play a key role in the morbidity and pathogenesis of these infections. Nitric oxide (NO) is a naturally produced free radical with proven bactericidal effect. In this study, Foley urinary catheters were impregnated with gaseous NO. The catheters demonstrated slow release of nitric oxide over a 14-day period. The charged catheters were rendered antiseptic, and as such, were able to prevent bacterial colonization and biofilm formation on their luminal and exterior surfaces. In addition, we observed that NO-impregnated catheters were able to inhibit the growth of Escherichia coli within the surrounding media, demonstrating the ability to eradicate a bacterial concentration of up to 10(4) CFU/ml.

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