Colocation of the Polymyxin Resistance Gene mcr-1 and a Variant of mcr-3 on a Plasmid in an Escherichia coli Isolate from a Chicken Farm | Zendy

Rong Xiang | Zendy; Bihui Liu | Zendy; Anyun Zhang | Zendy; Changwei Lei | Zendy; Xiaolan Ye | Zendy; Yanxian Yang | Zendy; Yanpeng Chen | Zendy; Hongning Wang | Zendy

Open Access

Colocation of the Polymyxin Resistance Gene mcr-1 and a Variant of mcr-3 on a Plasmid in an Escherichia coli Isolate from a Chicken Farm

Author(s) -

Rong Xiang,

Bihui Liu,

Anyun Zhang,

Changwei Lei,

Xiaolan Ye,

Yanxian Yang,

Yanpeng Chen,

Hongning Wang

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00501-18

Subject(s) - mcr 1 , plasmid , polymyxin , escherichia coli , colistin , gene , biology , enterobacteriaceae , microbiology and biotechnology , genetics , antibiotics

A colistin-resistantEscherichia coli isolate from a commercial poultry farm in China carried two colistin resistance genes,mcr-1 and variant ofmcr-3 , in an IncP plasmid. The variant of themcr-3 gene, namedmcr-3.11 , encoded two amino acid substitutions compared with themcr-3 gene. A novel genetic structure, ISKpn40-mcr-3-dgkA -ISKpn40 , might be the key element mediating the translocation ofmcr-3 through the formation of a circular form. Themcr-1 andmcr-3 genes, which are colocated on a plasmid, might pose a huge threat to public health.

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