Decline and Rise of the Antimicrobial Susceptibility of Streptococcus pneumoniae Isolated from Middle Ear Fluid in Children: Influence of Changes in Circulating Serotypes | Zendy

Emilio PérezTrallero | Zendy; José María Marimón | Zendy; Marta Alonso | Zendy; María Ercibengoa | Zendy; J M García-Arenzana | Zendy

Open Access

Decline and Rise of the Antimicrobial Susceptibility of Streptococcus pneumoniae Isolated from Middle Ear Fluid in Children: Influence of Changes in Circulating Serotypes

Author(s) -

Emilio PérezTrallero,

José María Marimón,

Marta Alonso,

María Ercibengoa,

J M García-Arenzana

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00501-12

Subject(s) - streptococcus pneumoniae , serotype , antimicrobial , microbiology and biotechnology , otitis , pneumococcal infections , pneumococcal conjugate vaccine , biology , antibiotic resistance , virology , antibiotics , genetics

Changes in the antimicrobial susceptibility ofStreptococcus pneumoniae causing otitis media were studied in 916 isolates from children <5 years old between 1999 and 2010 in a region of northern Spain. The rate of antimicrobial resistance decreased between the period before the introduction of the heptavalent pneumococcal conjugate vaccine (from 1999 to 2001) and the period from 2005 to 2007. However, in 2008 to 2010, resistance rates increased again due to the spread of serotype 19A, especially the multidrug-resistant ST320 and ST276 clones.

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