Hepatitis C Virus (HCV) NS5B Nonnucleoside Inhibitors Specifically Block Single-Stranded Viral RNA Synthesis Catalyzed by HCV Replication Complexes In Vitro | Zendy

Wengang Yang | Zendy; Yongnian Sun | Zendy; Avinash Phadke | Zendy; Milind Deshpande | Zendy; Mingjun Huang | Zendy

Open Access

Hepatitis C Virus (HCV) NS5B Nonnucleoside Inhibitors Specifically Block Single-Stranded Viral RNA Synthesis Catalyzed by HCV Replication Complexes In Vitro

Author(s) -

Wengang Yang,

Yongnian Sun,

Avinash Phadke,

Milind Deshpande,

Mingjun Huang

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00498-06

Subject(s) - ns5b , virology , rna , hepatitis c virus , rna dependent rna polymerase , viral replication , in vitro , virus , biology , chemistry , hepacivirus , biochemistry , gene

Replication complexes of hepatitis C virus synthesized two major species of viral RNA in vitro, double stranded and single stranded. NS5B nonnucleoside inhibitors inhibited dose dependently the synthesis of single-stranded RNA but not double-stranded RNA. Moreover, replication complexes carrying a mutation resistant to a nonnucleoside inhibitor lost their susceptibilities to the inhibitor.

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