Open AccessStructural Insights into the Inhibition of the Extended-Spectrum β-Lactamase PER-2 by Avibactam
Author(s) -
Melina Ruggiero,
Krisztina M. PappWallace,
Florencia Brunetti,
Melissa D. Barnes,
Robert A. Bonomo,
Gabriel Gutkind,
Sebastián Klinke,
P.P. Power
Publication year - 2019
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00487-19
Subject(s) - avibactam , beta lactamase inhibitors , ceftazidime/avibactam , chemistry , computational biology , biology , stereochemistry , antibiotics , biochemistry , enterobacteriaceae , escherichia coli , gene
The diazabicyclooctane (DBO) avibactam (AVI) reversibly inactivates most serine-β-lactamases.
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