Comparative In Vitro Activity Profiles of Novel Bis-Indole Antibacterials against Gram-Positive and Gram-Negative Clinical Isolates | Zendy

Michelle M. Butler | Zendy; John D. Williams | Zendy; Norton P. Peet | Zendy; Donald T. Moir | Zendy; Rekha G. Panchal | Zendy; Sina Bavari | Zendy; Dean L. Shinabarger | Zendy; Terry L. Bowlin | Zendy

Open Access

Comparative In Vitro Activity Profiles of Novel Bis-Indole Antibacterials against Gram-Positive and Gram-Negative Clinical Isolates

Author(s) -

Michelle M. Butler,

John D. Williams,

Norton P. Peet,

Donald T. Moir,

Rekha G. Panchal,

Sina Bavari,

Dean L. Shinabarger,

Terry L. Bowlin

Publication year - 2010

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00484-10

Subject(s) - gram , antibiotics , antimicrobial , microbiology and biotechnology , indole test , gram negative bacteria , gram positive bacteria , biology , in vitro , multiple drug resistance , bacteria , chemistry , escherichia coli , biochemistry , genetics , gene

Antimicrobial susceptibilities of 233 Gram-positive and 180 Gram-negative strains to two novel bis-indoles were evaluated. Both compounds were potent inhibitors of Gram-positive bacteria, with MIC90 values of 0.004 to 0.5 μg/ml. One bis-indole, MBX 1162, exhibited potent activity against all Gram-negative strains, with MIC90 values of 0.12 to 4 μg/ml, even against high-level-resistant pathogens, and compared favorably to all comparator antibiotics. The bis-indole compounds show promise for the treatment of multidrug-resistant clinical pathogens.

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