Retapamulin Inhibition of Translation and 50S Ribosomal Subunit Formation in Staphylococcus aureus Cells | Zendy

W. Scott Champney | Zendy; Ward Rodgers | Zendy

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Retapamulin Inhibition of Translation and 50S Ribosomal Subunit Formation in Staphylococcus aureus Cells

Author(s) -

W. Scott Champney,

Ward Rodgers

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00475-07

Subject(s) - 50s , 23s ribosomal rna , ribosomal rna , staphylococcus aureus , ribosome , protein subunit , ribosomal protein , microbiology and biotechnology , biology , chemistry , bacteria , biochemistry , rna , gene , genetics

Retapamulin inhibited protein biosynthesis and cell viability in methicillin-sensitive and methicillin-resistant Staphylococcus aureus organisms. A specific inhibitory effect on 50S ribosomal subunit formation was also found. Pulse-chase labeling experiments confirmed the specific inhibition of 50S subunit biogenesis. Turnover of 23S rRNA was found, with no effect on 16S rRNA amounts.

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