Effect of DNase and Antibiotics on Biofilm Characteristics | Zendy

George Tetz | Zendy; N. K. Artemenko | Zendy; Victor Tetz | Zendy

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Effect of DNase and Antibiotics on Biofilm Characteristics

Author(s) -

George Tetz,

N. K. Artemenko,

Victor Tetz

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00471-08

Subject(s) - biofilm , bacteria , antibiotics , microbiology and biotechnology , extracellular , gram negative bacteria , biology , dna , extracellular polymeric substance , gram , extracellular matrix , chemistry , biochemistry , genetics , gene , escherichia coli

The role of extracellular DNA in the maintenance of biofilms formed by gram-positive and gram-negative bacteria was studied. This study evaluated all the bacterial strains that were tested for the presence of extracellular DNA with an average size of 30 kb in the matrix. Our results indicate changes in community biomass, architecture, morphology, and the numbers of CFU in the presence of DNase. This effect seems to be common to biofilms established by various unrelated gram-positive and gram-negative bacteria. The cleavage of extracellular DNA leads to the formation of an altered biofilm that permits the increased penetration of antibiotics. Thus, the addition of DNase enhances the effect of antibiotics, resulting in decreased biofilm biomass and numbers of CFU.

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