Tigecycline Induction of Phenol-Soluble Modulins by Invasive Methicillin-Resistant Staphylococcus aureus Strains | Zendy

Jason Yamaki | Zendy; Timothy W. Synold | Zendy; Annie WongBeringer | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Tigecycline Induction of Phenol-Soluble Modulins by Invasive Methicillin-Resistant Staphylococcus aureus Strains

Author(s) -

Jason Yamaki,

Timothy W. Synold,

Annie WongBeringer

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00470-13

Subject(s) - tigecycline , linezolid , clindamycin , microbiology and biotechnology , staphylococcus aureus , methicillin resistant staphylococcus aureus , antibiotics , hemolysin , biology , bacteria , vancomycin , virulence , biochemistry , gene , genetics

We examined the effects of tigecycline on three types of exoproteins, α-type phenol-soluble modulins (PSMα1 to PSMα4), α-hemolysin, and protein A, in 13 methicillin-resistant Staphylococcus aureus isolates compared to those of clindamycin and linezolid. Paradoxical increases in PSMαs occurred in 77% of the isolates with tigecycline at 1/4 and 1/8 MICs and clindamycin at 1/8 MIC compared to only 23% of the isolates with linezolid at 1/8 MIC. Induction was specific to PSMα1 to PSMα4, as protein A and α-hemolysin production was decreased under the same conditions by all of the antibiotics used.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research