Open AccessFluoroquinolone Enhances the Mutation Frequency for Meropenem-Selected Carbapenem Resistance in Pseudomonas aeruginosa , but Use of the High-Potency Drug Doripenem Inhibits Mutant Formation
Author(s) -
Koichi Tanimoto,
Haruyoshi Tomita,
Shuhei Fujimoto,
Katsuko Okuzumi,
Yasuyoshi Ike
Publication year - 2008
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00464-08
Subject(s) - doripenem , meropenem , pseudomonas aeruginosa , carbapenem , microbiology and biotechnology , mutant , biology , drug resistance , pseudomonadaceae , mutation , antibiotics , bacteria , antibiotic resistance , genetics , gene
The mutation frequency for carbapenem resistance inPseudomonas aeruginosa strains that were selected with carbapenems was enhanced in the presence of subinhibitory concentrations of fluoroquinolones. The mutants showed either a loss of OprD activity or increasedmexAB -oprM expression. The highest mutant isolation frequency was obtained by selection with meropenem, while doripenem inhibited mutant growth.