Fluoroquinolone Enhances the Mutation Frequency for Meropenem-Selected Carbapenem Resistance in Pseudomonas aeruginosa , but Use of the High-Potency Drug Doripenem Inhibits Mutant Formation | Zendy

Koichi Tanimoto | Zendy; Haruyoshi Tomita | Zendy; Shuhei Fujimoto | Zendy; Katsuko Okuzumi | Zendy; Yasuyoshi Ike | Zendy

Open Access

Fluoroquinolone Enhances the Mutation Frequency for Meropenem-Selected Carbapenem Resistance in Pseudomonas aeruginosa , but Use of the High-Potency Drug Doripenem Inhibits Mutant Formation

Author(s) -

Koichi Tanimoto,

Haruyoshi Tomita,

Shuhei Fujimoto,

Katsuko Okuzumi,

Yasuyoshi Ike

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00464-08

Subject(s) - doripenem , meropenem , pseudomonas aeruginosa , carbapenem , microbiology and biotechnology , mutant , biology , drug resistance , pseudomonadaceae , mutation , antibiotics , bacteria , antibiotic resistance , genetics , gene

The mutation frequency for carbapenem resistance inPseudomonas aeruginosa strains that were selected with carbapenems was enhanced in the presence of subinhibitory concentrations of fluoroquinolones. The mutants showed either a loss of OprD activity or increasedmexAB -oprM expression. The highest mutant isolation frequency was obtained by selection with meropenem, while doripenem inhibited mutant growth.

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