Effect of Anthrax Immune Globulin on Response to BioThrax (Anthrax Vaccine Adsorbed) in New Zealand White Rabbits | Zendy

Nina Malkevich | Zendy; Subhendu Basu | Zendy; Thomas L. Rudge | Zendy; Kristin H. Clement | Zendy; Ajoy C. Chakrabarti | Zendy; Ronald T. Aimes | Zendy; Gary S. Nabors | Zendy; Mario H. Skiadopoulos | Zendy; Б. И. Ионин | Zendy

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Effect of Anthrax Immune Globulin on Response to BioThrax (Anthrax Vaccine Adsorbed) in New Zealand White Rabbits

Author(s) -

Nina Malkevich,

Subhendu Basu,

Thomas L. Rudge,

Kristin H. Clement,

Ajoy C. Chakrabarti,

Ronald T. Aimes,

Gary S. Nabors,

Mario H. Skiadopoulos,

Б. И. Ионин

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00460-13

Subject(s) - anthrax vaccines , immune system , vaccination , immunology , antibody , virology , antigen , antibody response , anthrax toxin , microbiology and biotechnology , medicine , biology , immunization , dna vaccination , biochemistry , fusion protein , gene , recombinant dna

Development of anthrax countermeasures that may be used concomitantly in a postexposure setting requires an understanding of the interaction between these products. Anthrax immune globulin intravenous (AIGIV) is a candidate immunotherapeutic that contains neutralizing antibodies against protective antigen (PA), a component of anthrax toxins. We evaluated the interaction between AIGIV and BioThrax (anthrax vaccine adsorbed) in rabbits. While pharmacokinetics of AIGIV were not altered by vaccination, the vaccine-induced immune response was abrogated in AIGIV-treated animals.

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