Spider Venom Peptides for Gene Therapy of Chlamydia Infection | Zendy

В. Н. Лазарев | Zendy; Nadezhda F. Polina | Zendy; M. M. Shkarupeta | Zendy; E. S. Kostrjukova | Zendy; Alexander A. Vassilevski | Zendy; Sergey A. Kozlov | Zendy; Eugene V. Grishin | Zendy; Vadim M. Govorun | Zendy

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Spider Venom Peptides for Gene Therapy of Chlamydia Infection

Author(s) -

В. Н. Лазарев,

Nadezhda F. Polina,

M. M. Shkarupeta,

E. S. Kostrjukova,

Alexander A. Vassilevski,

Sergey A. Kozlov,

Eugene V. Grishin,

Vadim M. Govorun

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00449-11

Subject(s) - venom , biology , chlamydia trachomatis , antimicrobial peptides , doxycycline , spider , antimicrobial , gene , plasmid , microbiology and biotechnology , transfection , hek 293 cells , virology , antibiotics , genetics , biochemistry , zoology

Spider venoms are vast natural pharmacopoeias selected by evolution. The venom of the ant spider Lachesana tarabaevi contains a wide variety of antimicrobial peptides. We tested six of them (latarcins 1, 2a, 3a, 4b, 5, and cytoinsectotoxin 1a) for their ability to suppress Chlamydia trachomatis infection. HEK293 cells were transfected with plasmid vectors harboring the genes of the selected peptides. Controlled expression of the transgenes led to a significant decrease of C. trachomatis viability inside the infected cells.

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