20S Proteasome as a Drug Target in Trichomonas vaginalis | Zendy

Anthony J. O’Donoghue | Zendy; Betsaida BiboVerdugo | Zendy; Yukiko Miyamoto | Zendy; Steven C Wang | Zendy; Justin Yang | Zendy; Douglas E. Zuill | Zendy; Shoun Matsuka | Zendy; Zhenze Jiang | Zendy; Jehad Almaliti | Zendy; Conor R. Caffrey | Zendy; William H. Gerwick | Zendy; Lars Eckmann | Zendy

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20S Proteasome as a Drug Target in Trichomonas vaginalis

Author(s) -

Anthony J. O’Donoghue,

Betsaida BiboVerdugo,

Yukiko Miyamoto,

Steven C Wang,

Justin Yang,

Douglas E. Zuill,

Shoun Matsuka,

Zhenze Jiang,

Jehad Almaliti,

Conor R. Caffrey,

William H. Gerwick,

Lars Eckmann

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00448-19

Subject(s) - trichomonas vaginalis , trichomonas , drug , trichomonas vaginitis , microbiology and biotechnology , medicine , biology , pharmacology

Trichomoniasis is a sexually transmitted disease with hundreds of millions of annual cases worldwide. Approved treatment options are limited to two related nitro-heterocyclic compounds, yet resistance to these drugs is an increasing concern. New antimicrobials against the causative agent,Trichomonas vaginalis , are urgently needed.

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