Sodium Nitrite Inhibits Killing of Pseudomonas aeruginosa Biofilms by Ciprofloxacin | Zendy

Anna C. Zemke | Zendy; Brian R. Kocak | Zendy; Jennifer M. Bomberger | Zendy

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Sodium Nitrite Inhibits Killing of Pseudomonas aeruginosa Biofilms by Ciprofloxacin

Author(s) -

Anna C. Zemke,

Brian R. Kocak,

Jennifer M. Bomberger

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00448-16

Subject(s) - ciprofloxacin , sodium nitrite , pseudomonas aeruginosa , nitrite , biofilm , microbiology and biotechnology , cystic fibrosis , antimicrobial , bacteria , pseudomonas , chemistry , biology , antibiotics , food science , nitrate , genetics , organic chemistry

Sodium nitrite inhibits bacterial respiration and is in development as an antimicrobial for chronic bacterial infections associated with cystic fibrosis. The goal of the current study was to investigate the interaction between nitrite and ciprofloxacin. Using liquid culture killing assays and a biotic biofilm model, we observed that nitrite induces tolerance of ciprofloxacin.

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