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A plasmid carrying the colistin resistance genemcr-1 was isolated from a pig slurry sample in Estonia. The gene was present on a 33,311-bp plasmid of the IncX4 group.mcr-1 is the only antibiotic resistance gene on the plasmid, with the other genes mainly coding for proteins involved in conjugative DNA transfer (taxA ,taxB ,taxC ,trbM , and thepilX operon). The plasmid pESTMCR was present in three phylogenetically very differentEscherichia coli strains, suggesting that it has high potential for horizontal transfer.

antimicrobial agents and chemotherapy

Plasmid with Colistin Resistance Gene <i>mcr-1</i> in Extended-Spectrum-β-Lactamase-Producing Escherichia coli Strains Isolated from Pig Slurry in Estonia

Plasmid with Colistin Resistance Gene mcr-1 in Extended-Spectrum-β-Lactamase-Producing Escherichia coli Strains Isolated from Pig Slurry in Estonia