1 H -Benzo[ d ]Imidazole Derivatives Affect MmpL3 in Mycobacterium tuberculosis | Zendy

Małgorzata Korycka-Machała | Zendy; Albertus Viljoen | Zendy; Jakub Pawełczyk | Zendy; Paulina Borówka | Zendy; Bożena Dziadek | Zendy; Katarzyna Gobis | Zendy; Anna Brzostek | Zendy; Malwina Kawka | Zendy; Mickaël Blaise | Zendy; Dominik Strapagiel | Zendy; Laurent Kremer | Zendy; Jarosław Dziadek | Zendy

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1 H -Benzo[ d ]Imidazole Derivatives Affect MmpL3 in Mycobacterium tuberculosis

Author(s) -

Małgorzata Korycka-Machała,

Albertus Viljoen,

Jakub Pawełczyk,

Paulina Borówka,

Bożena Dziadek,

Katarzyna Gobis,

Anna Brzostek,

Malwina Kawka,

Mickaël Blaise,

Dominik Strapagiel,

Laurent Kremer,

Jarosław Dziadek

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00441-19

Subject(s) - mycolic acid , mycobacterium tuberculosis , biochemistry , biology , mutant , chemistry , mycobacterium , bacteria , gene , tuberculosis , medicine , genetics , pathology

1H -benzo[d ]imidazole derivatives exhibit antitubercular activityin vitro at a nanomolar range of concentrations and are not toxic to human cells, but their mode of action remains unknown. Here, we showed that these compounds are active against intracellularMycobacterium tuberculosis .

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