Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China | Zendy

Hua Yu | Zendy; Fen Qu | Zendy; Bin Shan | Zendy; Bin Huang | Zendy; Wei Jia | Zendy; Chen Cha | Zendy; Aiqing Li | Zendy; Minhui Miao | Zendy; Xin Zhang | Zendy; Chunmei Bao | Zendy; Yunmin Xu | Zendy; Kalyan D. Chavda | Zendy; YiWei Tang | Zendy; Barry N. Kreiswirth | Zendy; Hong Du | Zendy; Liang Chen | Zendy

Open Access

Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China

Author(s) -

Hua Yu,

Fen Qu,

Bin Shan,

Bin Huang,

Wei Jia,

Chen Cha,

Aiqing Li,

Minhui Miao,

Xin Zhang,

Chunmei Bao,

Yunmin Xu,

Kalyan D. Chavda,

YiWei Tang,

Barry N. Kreiswirth,

Hong Du,

Liang Chen

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00440-16

Subject(s) - mcr 1 , enterobacteriaceae , colistin , enterobacteriaceae infections , microbiology and biotechnology , carbapenem resistant enterobacteriaceae , polymyxin , carbapenem , china , biology , gene , medicine , antibiotics , escherichia coli , genetics , geography , archaeology

The spread of the plasmid-mediated colistin resistance gene, mcr-1, into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1-harboring carbapenem-resistant Escherichia coli strains, collected from three patients in two provinces in China. Our results show that mcr-1-harboring CRE strains have started to spread in different hospitals in China. In addition, this report presents the first description of chromosomal integration of mcr-1 into a carbapenem-resistant E. coli strain.

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