Nonspecific Effect of Mycograb on Amphotericin B MIC | Zendy

Daryl L. Richie | Zendy; Mahmoud A. Ghannoum | Zendy; N. Isham | Zendy; Kylie Thompson | Zendy; Neil S. Ryder | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Nonspecific Effect of Mycograb on Amphotericin B MIC

Author(s) -

Daryl L. Richie,

Mahmoud A. Ghannoum,

N. Isham,

Kylie Thompson,

Neil S. Ryder

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00435-12

Subject(s) - amphotericin b , in vivo , checkerboard , in vitro , recombinant dna , antibody , microbiology and biotechnology , pharmacology , biology , chemistry , immunology , antifungal , biochemistry , gene

Mycograb C28Y is a recombinant human antibody fragment thought to target HSP-90 and potentiate amphotericin B (AMB). Absence ofin vivo efficacy led us to reevaluate itsin vitro activity. Interactions between AMB and Mycograb were investigated using a checkerboard design. Addition of Mycograb or various unrelated proteins, including human serum, resulted in similar decreases in the MIC of AMB. Potentiation of AMB by Mycograb appears to be a nonspecific protein effect.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research