Identification of Novel Mutations in LprG ( rv1411c ), rv0521 , rv3630 , rv0010c , ppsC , and cyp128 Associated with Pyrazinoic Acid/Pyrazinamide Resistance in Mycobacterium tuberculosis | Zendy

Wanliang Shi | Zendy; Jiazhen Chen | Zendy; Shuo Zhang | Zendy; Wenhong Zhang | Zendy; Ying Zhang | Zendy

Open Access

Identification of Novel Mutations in LprG ( rv1411c ), rv0521 , rv3630 , rv0010c , ppsC , and cyp128 Associated with Pyrazinoic Acid/Pyrazinamide Resistance in Mycobacterium tuberculosis

Author(s) -

Wanliang Shi,

Jiazhen Chen,

Shuo Zhang,

Wenhong Zhang,

Ying Zhang

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00430-18

Subject(s) - pyrazinamide , mutant , genetics , biology , mutation , gene , antibiotics , rifampicin

Despite progress, the mechanisms of action and resistance of pyrazinamide (PZA) are not well understood. We characterized 109 mutants resistant to pyrazinoic acid (POA), the active form of PZA, and found that while most (n = 101 [93%]) mutants hadpanD mutations and 4 (4%) hadclpC1 mutations (S91G), new mutations inlprG (rv1411c ) andrv0521 (n = 4 [4%]),rv3630 ,rv0010c ,ppsC , andcyp128 (cytochrome P450 128) were identified, shedding new light on the mechanisms of action and resistance of PZA inM. tuberculosis .

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