Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures | Zendy

Giulia Menchinelli | Zendy; Flora Marzia Liotti | Zendy; Liliana Giordano | Zendy; Giulia De Angelis | Zendy; Maurizio Sanguinetti | Zendy; Teresa Spanu | Zendy; Brunella Posteraro | Zendy

Open Access

Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures

Author(s) -

Giulia Menchinelli,

Flora Marzia Liotti,

Liliana Giordano,

Giulia De Angelis,

Maurizio Sanguinetti,

Teresa Spanu,

Brunella Posteraro

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00420-19

Subject(s) - antimicrobial , drug , microbiology and biotechnology , blood culture , anti infective agents , medicine , antimicrobial drug , antibiotics , chemistry , pharmacology , biology

We assessed the antimicrobial-inactivation capability of BacT/Alert (FA Plus and FN Plus) or Bactec (Plus Aerobic/F and Plus Anaerobic/F) media for 40 antibiotic-bacterium combinations in simulated adult blood cultures. Aside from high recovery rates (93.2% and 88.4%, respectively), we showed that at the lowest but clinically relevant antibiotic concentrations, both BacT/Alert and Bactec media recovered all the organisms tested with drugs except forEscherichia coli , which was tested in the presence of meropenem.

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