Kinetic Driver of Antibacterial Drugs against Plasmodium falciparum and Implications for Clinical Dosing | Zendy

Emily Caton | Zendy; Elizabeth Nenortas | Zendy; Rahul P. Bakshi | Zendy; Theresa A. Shapiro | Zendy

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Kinetic Driver of Antibacterial Drugs against Plasmodium falciparum and Implications for Clinical Dosing

Author(s) -

Emily Caton,

Elizabeth Nenortas,

Rahul P. Bakshi,

Theresa A. Shapiro

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00416-19

Subject(s) - plasmodium falciparum , ciprofloxacin , pharmacology , pharmacokinetics , clindamycin , malaria , dosing , pharmacodynamics , antibiotics , biology , medicine , microbiology and biotechnology , immunology

Antibacterial drugs are an important component of malaria therapy. We studied the interactions of clindamycin, tetracycline, chloramphenicol, and ciprofloxacin againstPlasmodium falciparum under static and dynamic conditions. In microtiter plate assays (static conditions), and as expected, parasites displayed the delayed death response characteristic for apicoplast-targeting drugs.

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