Open AccessOverexpression of the adeB Gene in Clinical Isolates of Tigecycline-Nonsusceptible Acinetobacter baumannii without Insertion Mutations in adeRS
Author(s) -
JunRen Sun,
Ming-Chin Chan,
TeinYao Chang,
Weiyao Wang,
TzongShi Chiueh
Publication year - 2010
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00414-10
Subject(s) - tigecycline , acinetobacter baumannii , neisseriaceae , gene , biology , microbiology and biotechnology , genetics , virology , antibiotics , bacteria , pseudomonas aeruginosa
Thirteen clinical isolates ofm ultidrug-r esistantAcinetobacter baumannii r esistant toc arbapenems (MRAB-C) with tigecycline nonsusceptibility were collected from individual patients in this study. None of the 13 isolates shared the same strain characteristics in molecular typing. All of them showed increasedadeB transcription, as predicted. However, none of these tigecycline-nonsusceptible MRAB-C isolates were found to possess previously knownadeRS mutations. Upregulation ofadeB transcription may result from cross stimulation by other mechanisms.