Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae Mediated by Chromosomal Integration of Plasmid DNA | Zendy

Astrid V. Cienfuegos-Gallet | Zendy; Liang Chen | Zendy; Barry N. Kreiswirth | Zendy; J. Natalia Jiménez | Zendy

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Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae Mediated by Chromosomal Integration of Plasmid DNA

Author(s) -

Astrid V. Cienfuegos-Gallet,

Liang Chen,

Barry N. Kreiswirth,

J. Natalia Jiménez

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00404-17

Subject(s) - klebsiella pneumoniae , colistin , plasmid , biology , microbiology and biotechnology , carbapenem , insertion sequence , locus (genetics) , dna , genetics , gene , escherichia coli , antibiotics , genome , transposable element

Here we describe the spread of colistin resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae in Medellín, Colombia. Among 32 isolates collected between 2012 and 2014, 24 showed genetic alterations in mgrB Nineteen isolates belonged to sequence type 512 (ST512) (or its single locus variant [SLV]) and harbored an 8.1-kb hsdMSR insertion corresponding to IS Kpn25 , indicating a clonal expansion of the resistant strain. The insertion region showed 100% identity to several plasmids, suggesting that the colistin resistance is mediated by chromosomal integration of plasmid DNA.

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