Role of the ABC Transporter PRP1 (ABCC7) in Pentamidine Resistance in Leishmania Amastigotes | Zendy

Adriano C. Coelho | Zendy; Nadine Messier | Zendy; Marc Ouellette | Zendy; Paulo C. Cotrim | Zendy

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Role of the ABC Transporter PRP1 (ABCC7) in Pentamidine Resistance in Leishmania Amastigotes

Author(s) -

Adriano C. Coelho,

Nadine Messier,

Marc Ouellette,

Paulo C. Cotrim

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00404-07

Subject(s) - pentamidine , amastigote , leishmania , leishmaniasis , intracellular , atp binding cassette transporter , microbiology and biotechnology , kinetoplastida , biology , intracellular parasite , virology , transporter , immunology , parasite hosting , protozoal disease , medicine , gene , biochemistry , world wide web , computer science , malaria , pneumonia

Pentamidine is a second-line agent in the treatment of leishmaniasis whose mode of action and resistance mechanism are not well understood. In this work, we show that the intracellular ABC protein PRP1 (pentamidine resistance protein 1) (ABCC7) can confer resistance to pentamidine in Leishmania sp. parasites in the intracellular stage.

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