Role of Plasma Proteins in Pharmacokinetics of Micafungin, an Antifungal Antibiotic, in Analbuminemic Rats | Zendy

Fumie Abe | Zendy; Jun Ueyama | Zendy; Noriyo Kawasumi | Zendy; Masayuki Nadai | Zendy; Tamon Hayashi | Zendy; Miki Kato | Zendy; Masafumi Ohnishi | Zendy; Hiroko Saito | Zendy; Naoshi Takeyama | Zendy; Takaaki Hasegawa | Zendy

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Role of Plasma Proteins in Pharmacokinetics of Micafungin, an Antifungal Antibiotic, in Analbuminemic Rats

Author(s) -

Fumie Abe,

Jun Ueyama,

Noriyo Kawasumi,

Masayuki Nadai,

Tamon Hayashi,

Miki Kato,

Masafumi Ohnishi,

Hiroko Saito,

Naoshi Takeyama,

Takaaki Hasegawa

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00396-08

Subject(s) - micafungin , pharmacokinetics , multidrug resistance associated protein 2 , pharmacology , globulin , albumin , antibiotics , bioconcentration , echinocandins , blood proteins , antifungal , medicine , chemistry , biology , microbiology and biotechnology , biochemistry , amphotericin b , atp binding cassette transporter , transporter , bioaccumulation , organic chemistry , caspofungin , gene

There were no significant differences in the pharmacokinetics of micafungin and expression of hepatic multidrug resistance-associated protein 2 (ABCC2/Mrp2) between analbuminemic and Sprague-Dawley rats. Micafungin bound strongly to high-density lipoprotein (HDL) and moderately to gamma globulin. These results suggest that HDL and gamma globulin contribute to the pharmacokinetics of micafungin.

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