Emergence of Klebsiella pneumoniae Coproducing KPC-2 and 16S rRNA Methylase ArmA in Poland | Zendy

Katarzyna Zacharczuk | Zendy; Katarzyna Piekarska | Zendy; J Szych | Zendy; E Zawidzka | Zendy; Agnieszka Sulikowska | Zendy; Sebastian Wardak | Zendy; Marek Jagielski | Zendy; Rafał Gierczyński | Zendy

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Emergence of Klebsiella pneumoniae Coproducing KPC-2 and 16S rRNA Methylase ArmA in Poland

Author(s) -

Katarzyna Zacharczuk,

Katarzyna Piekarska,

J Szych,

E Zawidzka,

Agnieszka Sulikowska,

Sebastian Wardak,

Marek Jagielski,

Rafał Gierczyński

Publication year - 2010

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00386-10

Subject(s) - klebsiella pneumoniae , microbiology and biotechnology , pulsed field gel electrophoresis , 16s ribosomal rna , biology , plasmid , klebsiella infections , strain (injury) , klebsiella , genotype , virology , gene , genetics , escherichia coli , anatomy

A Klebsiella pneumoniae epidemic strain that coproduced carbapenemase KPC-2 (K. pneumoniae carbapenemase 2) and 16S rRNA methylase ArmA has emerged in Poland. Four nonduplicate isolates from patients in a hospital in Warsaw, Poland, were found to carry the bla(KPC-2) and armA genes on ca. 50-kb and 90-kb plasmids, respectively. Tn4401 with a 100-bp deletion in the variable region was detected in all the isolates. XbaI pulsed-field gel electrophoresis (PFGE) revealed 93.2% similarity of the isolates. All the isolates were resistant to carbapenems and 4,6-disubstituted 2-deoxystreptamines.

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