Clonal Dissemination of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae in Neonates | Zendy

Dandan Yin | Zendy; Dong Dong | Zendy; Ke Li | Zendy; Lei Zhang | Zendy; Jianliang Liang | Zendy; Yang Yang | Zendy; Nana Wu | Zendy; Yiyan Bao | Zendy; Chuanqing Wang | Zendy; Fupin Hu | Zendy

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Clonal Dissemination of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae in Neonates

Author(s) -

Dandan Yin,

Dong Dong,

Ke Li,

Lei Zhang,

Jianliang Liang,

Yang Yang,

Nana Wu,

Yiyan Bao,

Chuanqing Wang,

Fupin Hu

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00385-17

Subject(s) - klebsiella pneumoniae , microbiology and biotechnology , klebsiella infections , enterobacteriaceae , bacterial protein , biology , enterobacteriaceae infections , medicine , virology , escherichia coli , bacteria , gene , genetics

Five OXA-232 carbapenemase-producingKlebsiella pneumoniae isolates, belonging to the pandemic clone sequence type 15 (ST15), were isolated from neonates and coproducedbla CTX-M-15 andbla SHV-1 genes. All isolates were resistant to ertapenem (MICs of >32 μg/ml) and meropenem (MICs of 4 to 8 μg/ml) and susceptible or intermediate to imipenem (MICs of 1 to 2 μg/ml). Thebla OXA-232 gene was located on a ColE-type transformable plasmid of 6,141 bp. To the best of our knowledge, this is the first report of OXA-232 carbapenemase among clinical isolates in China.

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