Clinical Correlation of the CLSI Susceptibility Breakpoint for Piperacillin- Tazobactam against Extended-Spectrum-β-Lactamase-Producing Escherichia coli and Klebsiella Species | Zendy

Patrick J. Gavin | Zendy; Mira Suseno | Zendy; Richard B. Thomson | Zendy; J. Michael Gaydos | Zendy; Carl L. Pierson | Zendy; Diane Halstead | Zendy; Jaber Aslanzadeh | Zendy; Stephen M. Brecher | Zendy; Coleman Rotstein | Zendy; Stephen E. Brossette | Zendy; Lance R. Peterson | Zendy

Open Access

Clinical Correlation of the CLSI Susceptibility Breakpoint for Piperacillin- Tazobactam against Extended-Spectrum-β-Lactamase-Producing Escherichia coli and Klebsiella Species

Author(s) -

Patrick J. Gavin,

Mira Suseno,

Richard B. Thomson,

J. Michael Gaydos,

Carl L. Pierson,

Diane Halstead,

Jaber Aslanzadeh,

Stephen M. Brecher,

Coleman Rotstein,

Stephen E. Brossette,

Lance R. Peterson

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00381-05

Subject(s) - piperacillin , breakpoint , tazobactam , piperacillin/tazobactam , microbiology and biotechnology , escherichia coli , klebsiella , biology , enterobacteriaceae , klebsiella pneumoniae , beta lactamase , antibiotics , antibiotic resistance , bacteria , imipenem , pseudomonas aeruginosa , genetics , chromosomal translocation , gene

We assessed infections caused by extended-spectrum-β-lactamase-producingEscherichia coli orKlebsiella spp. treated with piperacillin-tazobactam to determine if the susceptibility breakpoint predicts outcome. Treatment was successful in 10 of 11 nonurinary infections from susceptible strains and in 2 of 6 infections with MICs of >16/4 μg/ml. All six urinary infections responded to treatment regardless of susceptibility.

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