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We assessed infections caused by extended-spectrum-β-lactamase-producingEscherichia coli orKlebsiella spp. treated with piperacillin-tazobactam to determine if the susceptibility breakpoint predicts outcome. Treatment was successful in 10 of 11 nonurinary infections from susceptible strains and in 2 of 6 infections with MICs of &gt;16/4 μg/ml. All six urinary infections responded to treatment regardless of susceptibility.

antimicrobial agents and chemotherapy

Clinical Correlation of the CLSI Susceptibility Breakpoint for Piperacillin- Tazobactam against Extended-Spectrum-β-Lactamase-Producing <i>Escherichia coli</i> and <i>Klebsiella</i> Species

Clinical Correlation of the CLSI Susceptibility Breakpoint for Piperacillin- Tazobactam against Extended-Spectrum-β-Lactamase-Producing Escherichia coli and Klebsiella Species