Phage Therapy of Pneumonia Is Not Associated with an Overstimulation of the Inflammatory Response Compared to Antibiotic Treatment in Mice | Zendy

Nicolas Dufour | Zendy; Raphaëlle Delattre | Zendy; Anne Chevallereau | Zendy; Jean-Damien Ricard | Zendy; Laurent Debarbieux | Zendy

Open Access

Phage Therapy of Pneumonia Is Not Associated with an Overstimulation of the Inflammatory Response Compared to Antibiotic Treatment in Mice

Author(s) -

Nicolas Dufour,

Raphaëlle Delattre,

Anne Chevallereau,

Jean-Damien Ricard,

Laurent Debarbieux

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00379-19

Subject(s) - phage therapy , bacteriophage , pneumonia , antibiotics , medicine , immunology , intensive care medicine , host response , antibiotic therapy , microbiology and biotechnology , biology , immune system , escherichia coli , biochemistry , gene

Supported by years of clinical use in some countries and more recently by literature on experimental models, as well as its compassionate use in Europe and in the United States, bacteriophage (phage) therapy is providing a solution for difficult-to-treat bacterial infections. However, studies of the impact of such treatments on the host remain scarce.

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