Population Pharmacokinetics of Anidulafungin in Critically Ill Patients | Zendy

Sònia Luque | Zendy; William Hope | Zendy; Nuria E. Campillo | Zendy; Rosana Muñoz-Bermúdez | Zendy; Luisa Sorlí | Zendy; Jaime BarcelóVidal | Zendy; E González-Colominas | Zendy; Francisco Álvarez-Lerma | Zendy; Joan Ramón Masclans | Zendy; M. Montero | Zendy; Juan Pablo Horcajada | Zendy; Santiago Grau | Zendy

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Population Pharmacokinetics of Anidulafungin in Critically Ill Patients

Author(s) -

Sònia Luque,

William Hope,

Nuria E. Campillo,

Rosana Muñoz-Bermúdez,

Luisa Sorlí,

Jaime BarcelóVidal,

E González-Colominas,

Francisco Álvarez-Lerma,

Joan Ramón Masclans,

M. Montero,

Juan Pablo Horcajada,

Santiago Grau

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00378-19

Subject(s) - anidulafungin , pharmacokinetics , critically ill , nonmem , medicine , population , population pharmacokinetics , candida albicans , candida glabrata , intensive care medicine , pharmacology , fluconazole , biology , micafungin , antifungal , microbiology and biotechnology , environmental health , dermatology

A two-compartment pharmacokinetic (PK) population model of anidulafungin was fitted to PK data from 23 critically ill patients (age, 65 years [range, 28 to 81 years]; total body weight [TBW], 75 kg [range, 54 to 168 kg]). TBW was associated with clearance and incorporated into a final population PK model.

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