Novel Self-Assembled Micelles Based on Cholesterol-Modified Antimicrobial Peptide (DP7) for Safe and Effective Systemic Administration in Animal Models of Bacterial Infection | Zendy

Rui Zhang | Zendy; Fengbo Wu | Zendy; Lei Wu | Zendy; Yaomei Tian | Zendy; Bailing Zhou | Zendy; Xueyan Zhang | Zendy; Rong Huang | Zendy; Chaoheng Yu | Zendy; Gu He | Zendy; Li Yang | Zendy

Open Access

Novel Self-Assembled Micelles Based on Cholesterol-Modified Antimicrobial Peptide (DP7) for Safe and Effective Systemic Administration in Animal Models of Bacterial Infection

Author(s) -

Rui Zhang,

Fengbo Wu,

Lei Wu,

Yaomei Tian,

Bailing Zhou,

Xueyan Zhang,

Rong Huang,

Chaoheng Yu,

Gu He,

Li Yang

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00368-18

Subject(s) - micelle , antimicrobial , hemolysis , drug , pharmacology , antimicrobial peptides , immune system , systemic administration , amphiphile , conjugate , peptide , cholesterol , chemistry , microbiology and biotechnology , drug resistance , in vivo , medicine , biology , aqueous solution , immunology , biochemistry , mathematical analysis , mathematics , organic chemistry , copolymer , polymer

Owing to their broad-spectrum antibacterial properties, multitarget effects, and low drug resistance, antimicrobial peptides (AMPs) have played critical roles in the clinical therapy of drug-resistant bacterial infections. However, the potential hazard of hemolysis following systemic administration has greatly limited their application.

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