Open AccessIn Vitro Activity of Polymyxin B plus Imipenem, Meropenem, or Tigecycline against KPC-2-Producing Enterobacteriaceae with High MICs for These Antimicrobials
Author(s) -
Natália Barth,
Vanessa Bley Ribeiro,
Alexandre Prehn Zavascki
Publication year - 2015
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00365-15
Subject(s) - tigecycline , meropenem , polymyxin b , microbiology and biotechnology , enterobacter cloacae , polymyxin , enterobacteriaceae , imipenem , klebsiella pneumoniae , serratia marcescens , antimicrobial , biology , antibacterial agent , antibiotics , antibiotic resistance , escherichia coli , biochemistry , gene
We evaluated thein vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against six KPC-2-producingEnterobacteriaceae strains with high MICs for these antimicrobial agents. Polymyxin B with carbapenems, especially meropenem, were the most active combinations forKlebsiella pneumoniae andEnterobacter cloacae regardless of the polymyxin B concentration used in the time-kill assay. This combination was also synergistic against twoSerratia marcescens strains that are intrinsically resistant to polymyxins. Polymyxin B and tigecycline also presented synergistic activity in most experiments.
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