Assessment by Time-Kill Methodology of the Synergistic Effects of Oritavancin in Combination with Other Antimicrobial Agents against Staphylococcus aureus | Zendy

Adam Belley | Zendy; Eve Neesham-Gre | Zendy; Francis F. Arhin | Zendy; Geoffrey A. McKay | Zendy; Thomas Parr | Zendy; Greg Moeck | Zendy

Open Access

Assessment by Time-Kill Methodology of the Synergistic Effects of Oritavancin in Combination with Other Antimicrobial Agents against Staphylococcus aureus

Author(s) -

Adam Belley,

Eve Neesham-Gre,

Francis F. Arhin,

Geoffrey A. McKay,

Thomas Parr,

Greg Moeck

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00361-08

Subject(s) - linezolid , vancomycin , staphylococcus aureus , antimicrobial , moxifloxacin , methicillin resistant staphylococcus aureus , gentamicin , microbiology and biotechnology , antibiotics , medicine , pharmacology , chemistry , biology , bacteria , genetics

Oritavancin is a semisynthetic lipoglycopeptide in clinical development for serious gram-positive infections. This study describes the synergistic activity of oritavancin in combination with gentamicin, linezolid, moxifloxacin, or rifampin in time-kill studies against methicillin-susceptible, vancomycin-intermediate, and vancomycin-resistant Staphylococcus aureus.

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