Spread of Plasmids Carrying Multiple GES Variants | Zendy

Gaëlle Cuzon | Zendy; Pierre Bogaerts | Zendy; Caroline Bauraing | Zendy; TeDin Huang | Zendy; Rémy A. Bonnin | Zendy; Y. Glupczynski | Zendy; Thierry Naas | Zendy

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Spread of Plasmids Carrying Multiple GES Variants

Author(s) -

Gaëlle Cuzon,

Pierre Bogaerts,

Caroline Bauraing,

TeDin Huang,

Rémy A. Bonnin,

Y. Glupczynski,

Thierry Naas

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00360-16

Subject(s) - plasmid , integron , biology , enterobacter cloacae , enterobacteriaceae , microbiology and biotechnology , genetics , whole genome sequencing , horizontal gene transfer , genome , gene , escherichia coli

Five GES-producing Enterobacteriaceae isolates that displayed an extended-spectrum β-lactamase (ESBL) phenotype harbored two GES variants: GES-7 ESBL and GES-6 carbapenemase. In all isolates, the two GES alleles were located on the same integron that was inserted into an 80-kb IncM1 self-conjugative plasmid. Whole-genome sequencing suggested in vivo horizontal gene transfer of the plasmid along with clonal diffusion of Enterobacter cloacae To our knowledge, this is the first description in Europe of clustered Enterobacteriaceae isolates carrying two GES β-lactamases, of which one has extended activity toward carbapenems.

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