Deciphering Heteroresistance to Colistin in a Klebsiella pneumoniae Isolate from Marseille, France | Zendy

Lucie Bardet | Zendy; Sophie Alexandra Baron | Zendy; Thongpan Leangapichart | Zendy; Liliane Okdah | Zendy; Seydina M. Diene | Zendy; JeanMarc Rolain | Zendy

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Deciphering Heteroresistance to Colistin in a Klebsiella pneumoniae Isolate from Marseille, France

Author(s) -

Lucie Bardet,

Sophie Alexandra Baron,

Thongpan Leangapichart,

Liliane Okdah,

Seydina M. Diene,

JeanMarc Rolain

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00356-17

Subject(s) - colistin , klebsiella pneumoniae , microbiology and biotechnology , antibiotics , biology , virology , medicine , gene , genetics , escherichia coli

Here, we report the description of a colistin-heteroresistant Klebsiella pneumoniae isolate fortuitously isolated from the stool sample of a patient with suspicion of tuberculosis in a public hospital of Marseille, France. In the colistin-resistant subpopulation, a mutation in the mgrB gene leading to a premature stop codon was found, and the hypermucoviscous phenotype was lost. Susceptibility to other antibiotics remained unchanged. To our knowledge, this is the first identification of such a colistin-heteroresistant Klebsiella pneumoniae isolate in France.

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