Open AccessEffect of Carbapenem Administration on Establishment of Intestinal Colonization by Vancomycin-Resistant Enterococci and Klebsiella pneumoniae in Mice
Author(s) -
Usha Stiefel,
Nicole J. Pultz,
Curtis J. Donskey
Publication year - 2007
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00355-06
Subject(s) - ertapenem , imipenem , klebsiella pneumoniae , microbiology and biotechnology , cilastatin , colonization , carbapenem , antibiotics , imipenem/cilastatin , vancomycin , biology , medicine , bacteria , escherichia coli , staphylococcus aureus , antibiotic resistance , biochemistry , gene , genetics
In a mouse model, ertapenem inhibited the anaerobic intestinal microflora and promoted overgrowth of enterococci, whereas imipenem-cilastatin had no effect on the indigenous microflora. Ertapenem, but not imipenem-cilastatin, promoted modest overgrowth of vancomycin-resistant enterococci when exposure occurred during treatment. Neither agent promoted colonization with extended-spectrum beta-lactamase-producingKlebsiella pneumoniae .