Effect of Carbapenem Administration on Establishment of Intestinal Colonization by Vancomycin-Resistant Enterococci and Klebsiella pneumoniae in Mice | Zendy

Usha Stiefel | Zendy; Nicole J. Pultz | Zendy; Curtis J. Donskey | Zendy

Open Access

Effect of Carbapenem Administration on Establishment of Intestinal Colonization by Vancomycin-Resistant Enterococci and Klebsiella pneumoniae in Mice

Author(s) -

Usha Stiefel,

Nicole J. Pultz,

Curtis J. Donskey

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00355-06

Subject(s) - ertapenem , imipenem , klebsiella pneumoniae , microbiology and biotechnology , cilastatin , colonization , carbapenem , antibiotics , imipenem/cilastatin , vancomycin , biology , medicine , bacteria , escherichia coli , staphylococcus aureus , antibiotic resistance , biochemistry , gene , genetics

In a mouse model, ertapenem inhibited the anaerobic intestinal microflora and promoted overgrowth of enterococci, whereas imipenem-cilastatin had no effect on the indigenous microflora. Ertapenem, but not imipenem-cilastatin, promoted modest overgrowth of vancomycin-resistant enterococci when exposure occurred during treatment. Neither agent promoted colonization with extended-spectrum beta-lactamase-producingKlebsiella pneumoniae .

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