Absence of K13 Polymorphism in Plasmodium falciparum from Brazilian Areas Where the Parasite Is Endemic | Zendy

Larissa Rodrigues Gomes | Zendy; Aline Lavigne | Zendy; Cassio Peterka | Zendy; Patrícia Brasil | Zendy; Didier Ménard | Zendy; Cláudio Tadeu DanielRibeiro | Zendy; Maria de Fátima FerreiradaCruz | Zendy

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Absence of K13 Polymorphism in Plasmodium falciparum from Brazilian Areas Where the Parasite Is Endemic

Author(s) -

Larissa Rodrigues Gomes,

Aline Lavigne,

Cassio Peterka,

Patrícia Brasil,

Didier Ménard,

Cláudio Tadeu DanielRibeiro,

Maria de Fátima FerreiradaCruz

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00354-18

Subject(s) - plasmodium falciparum , malaria , parasite hosting , artemisinin , biology , virology , apicomplexa , immunology , world wide web , computer science

Plasmodium falciparum artemisinin-resistant parasites can be evaluated by examining polymorphisms in the kelch ( PfK13 ) domain. A total of 69 samples from patients with falciparum malaria were analyzed. All samples were from areas in states in Brazil where the parasite was endemic: Acre ( n = 14), Amapá ( n = 15), Amazonas ( n = 30), and Pará ( n = 10). After DNA alignment with the 3D7 reference sequence, all samples were found to be wild type. These data provide a baseline for PfK13 and reinforce the pertinence of artemisinin combination therapy in Brazilian areas.

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