Antimicrobial Susceptibility and Cross-Resistance Patterns among Common Complicated Urinary Tract Infections in U.S. Hospitals, 2013 to 2018 | Zendy

Marya D. Zilberberg | Zendy; Brian H. Nathanson | Zendy; Kate Sulham | Zendy; Andrew F. Shorr | Zendy

Open Access

Antimicrobial Susceptibility and Cross-Resistance Patterns among Common Complicated Urinary Tract Infections in U.S. Hospitals, 2013 to 2018

Author(s) -

Marya D. Zilberberg,

Brian H. Nathanson,

Kate Sulham,

Andrew F. Shorr

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00346-20

Subject(s) - nitrofurantoin , trimethoprim , fosfomycin , medicine , antimicrobial , sulfamethoxazole , cephalosporin , urinary system , antibiotic resistance , urine , antimicrobial stewardship , antibiotics , microbiology and biotechnology , biology

In the face of increasing rates of antimicrobial resistance in complicated urinary tract infections (cUTIs), clinicians need to understand cross-resistance patterns among commonly encountered pathogens. We performed a multicenter, retrospective cohort study in the Premier database of approximately 180 hospitals, from 2013 to 2018. Using an ICD-9/10-based algorithm, we identified all adult patients hospitalized with cUTIs and included those with a positive blood or urine culture. We examined the microbiology and susceptibilities to common cUTI antimicrobials (3rd-generation cephalosporin [C3], fluoroquinolones [FQ], trimethoprim-sulfamethoxazole [TMP/SMZ], fosfomycin [FFM], and nitrofurantoin [NFT]) singly and in groups of two.

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