Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice | Zendy

Roger V. Ortines | Zendy; Yu Wang | Zendy; Haiyun Liu | Zendy; Dustin Dikeman | Zendy; Bret L. Pinsker | Zendy; Robert J. Miller | Zendy; Sophia E. Kim | Zendy; Nicole E. Ackerman | Zendy; Joe F. Rizkallah | Zendy; LeeAnn T. Marcello | Zendy; Taylor S. Cohen | Zendy; Christine Tkaczyk | Zendy; Bret R. Sellman | Zendy; Lloyd Miller | Zendy

Open Access

Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice

Author(s) -

Roger V. Ortines,

Yu Wang,

Haiyun Liu,

Dustin Dikeman,

Bret L. Pinsker,

Robert J. Miller,

Sophia E. Kim,

Nicole E. Ackerman,

Joe F. Rizkallah,

LeeAnn T. Marcello,

Taylor S. Cohen,

Christine Tkaczyk,

Bret R. Sellman,

Lloyd Miller

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00346-19

Subject(s) - staphylococcus aureus , monoclonal antibody , microbiology and biotechnology , vancomycin , micrococcaceae , medicine , staphylococcal infections , antibody , monoclonal , methicillin resistant staphylococcus aureus , antibiotics , antibacterial agent , immunology , biology , bacteria , genetics

Surgical site infections (SSIs) are commonly caused byStaphylococcus aureus . We report that a combination of three monoclonal antibodies (MEDI6389) that neutralizeS. aureus alpha-toxin, clumping factor A, and four leukocidins (LukSF, LukED, HlgAB, and HlgCB) plus vancomycin had enhanced efficacy compared with control antibody plus vancomycin in two mouse models ofS. aureus SSI.

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