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Surgical site infections (SSIs) are commonly caused byStaphylococcus aureus . We report that a combination of three monoclonal antibodies (MEDI6389) that neutralizeS. aureus alpha-toxin, clumping factor A, and four leukocidins (LukSF, LukED, HlgAB, and HlgCB) plus vancomycin had enhanced efficacy compared with control antibody plus vancomycin in two mouse models ofS. aureus SSI.

Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice