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Ceftolozane-tazobactam (C/T) is a novel cephalosporin within vitro activity againstPseudomonas aeruginosa that is resistant to extended-spectrum penicillins and antipseudomonal cephalosporins. In order to assess the antimicrobial effect of C/T in treatment ofPseudomonas pneumonia, we investigated the pharmacokinetics and efficacy of C/T in persistently neutropenic rabbits.Pseudomonas pneumonia was established by direct endotracheal inoculation.

antimicrobial agents and chemotherapy

Ceftolozane-Tazobactam in the Treatment of Experimental Pseudomonas aeruginosa Pneumonia in Persistently Neutropenic Rabbits: Impact on Strains with Genetically Defined Mechanisms of Resistance