In Vitro Activities of the Lipopeptides Palmitoyl (Pal)-Lys-Lys-NH 2 and Pal-Lys-Lys Alone and in Combination with Antimicrobial Agents against Multiresistant Gram-Positive Cocci | Zendy

Wojciech Kamysz | Zendy; Carmela Silvestri | Zendy; Oscar Cirioni | Zendy; Maria Carla Re | Zendy; Alberto Licci | Zendy; Agnese Della Vittoria | Zendy; Marcin Okrój | Zendy; Giorgio Scalise | Zendy

Open Access

In Vitro Activities of the Lipopeptides Palmitoyl (Pal)-Lys-Lys-NH ₂ and Pal-Lys-Lys Alone and in Combination with Antimicrobial Agents against Multiresistant Gram-Positive Cocci

Author(s) -

Wojciech Kamysz,

Carmela Silvestri,

Oscar Cirioni,

Maria Carla Re,

Alberto Licci,

Agnese Della Vittoria,

Marcin Okrój,

Giorgio Scalise

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00344-06

Subject(s) - microbiology and biotechnology , antimicrobial , rhodococcus equi , lipopeptide , vancomycin , in vitro , enterococcus , gram positive cocci , gram positive bacteria , biology , gram , antibiotics , chemistry , bacteria , staphylococcus aureus , biochemistry , genetics , virulence , gene

The in vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys against gram-positive cocci were investigated. Enterococci and streptococci demonstrated higher susceptibilities than staphylococci and Rhodococcus equi. A positive interaction was shown when the lipopeptides were combined with beta-lactams and vancomycin. These results suggest that lipopeptides are promising candidates for antimicrobial therapy for infections caused by gram-positive organisms.

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